When we resort to in vivo maturation of antibodies, cute and furry bunnies are our animal of choice, and here’s why. The rabbit immune system generates and affinity-matures antibodies by mechanisms that differ from those of mice and other rodents. Rabbit monoclonal antibodies normally have 10- to 100-fold higher affinity for antigen than mouse monoclonal antibodies. In addition, the rabbit immune system can generate antibodies that are able to distinguish between very similar molecules with subtle structural variations
We combine an optimized rabbit immunization protocol and our robust yeast display system, which is uniquely suited for rabbit antibodies that have an additional disulfide bond in their light chain.
The AvantBunny platform is ideal for the generation of high-specificity and high-affinity antibodies for critical reagents and diagnostics.
looking for biomarkers?
Funded by the National Cancer Institute, we generated monoclonal antibodies recognizing hundreds of cancer and neurodegenerative associated proteins. Below is an abbreviated list of validated antibodies and corresponding targets.
|RA-1017||Pkrcb (phospho T377)|
|DA-2005, DA-2006||Strep A|