The lightest of three from our Germliner™ Library Collection the AvantFoil platform is comprised of yeast-displayed antibodies in heavy chain only (VHH) format. We took heavy chain sequences from our human antibody database and further modified the framework to mimic camelid antibodies, which are naturally occurring heavy chain. only antibodies that lack a light chain. Our design minimizes potential immunogenicity and aggregation issues.
size does matter
VHHs are roughly one-tenth the weight of a full IgG antibody. They can target hard-to-reach epitopes and have faster diffusion properties.
15 billion clones
Every AvantFoil discovery project will introduce 1.5 x 1010 pre-made human antibody clones to your target of interest. We break the glass ceiling of yeast display library size by simply doing more and in parallel. The library is so large that we split the library into 3 sets by framework type.
cut to the chase
Our rapid screening methods, utilizing magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS), allow us to lunge and point to 25 to 100 unique and functional clones within weeks to months.
Our Germliner™ Library Collection represents many years of antibody sequencing and engineering. Over 500 individuals were deep-sequenced, amassing a large antibody repertoire that was then culled of potentially problematic sequence motifs. When coupled with our novel yeast display system, the end results are three fully human platforms with more than 100 billion antibody clones with highly favorable and developable properties, such as high affinity, high specificity, high thermostability, high expression level, and no or low immunogenicity.
Most potentially problematic sequence motifs have
been removed from the library
- iconGlycosylation sites
- iconIsomerization sites
- iconDeamidation sites
- iconCleavage sites
- iconOxidation sites
- iconFree cysteines