This is it. Our largest library from our Germliner™ Library Collection, the AvantSabre platform is comprised of yeast-displayed antibodies in Fab format. Fabs are composed of the light chain (VL + CL) and a heavy chain (VH + CH1) connected by an interchain disulfide bond. Fab is ideal for antibody therapeutics in either Fab or whole antibody format.
100 billion clones
Every AvantSabre discovery project will introduce 1011 pre-made human antibody clones to your target of interest. We break the glass ceiling of yeast display library size by simply doing more and in parallel. The library is so large that we split the library into 6 sets by framework type.
cut to the chase
Our rapid screening methods, utilizing magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS), allow us to slash and whittle down to 25 to 100 unique and functional clones within weeks to months.
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Our Germliner™ Library Collection represents many years of antibody sequencing and engineering. Over 500 individuals were deep-sequenced, amassing a large antibody repertoire that was then culled of potentially problematic sequence motifs. When coupled with our novel yeast display system, the end results are three fully human platforms with more than 100 billion antibody clones with highly favorable and developable properties, such as high affinity, high specificity, high thermostability, high expression level, and no or low immunogenicity.
acids in length
Most potentially problematic sequence motifs have
been removed from the library
- iconGlycosylation sites
- iconIsomerization sites
- iconDeamidation sites
- iconCleavage sites
- iconOxidation sites
- iconFree cysteines
Improved and non-biased display of diverse human antibody families compared to other systems.
In contrast, prokaryotic expression of bacteriophage coupled with constraints of assembly into the phage coat results in > 30-fold difference in antibody display between different variable region families as shown below. (Morphosys; mAbs 5:3, 445-70; 2013)
